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. 2020 Feb 16;12(4):3156–3174. doi: 10.18632/aging.102790

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Copyright © 2020 Xiang et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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MEG3 was a highly expressed lncRNA in IS that bonded with miR-424-5p. (A) The heatmap from the microarray analysis of GSE22255 showed the significantly differentially expressed lncRNAs including MEG3 in the IS group. (B) MEG3 bound to miR-424-5p and was related to IS. (C) MEG3 expression was positively correlated with OGD/R intervention time. *P<0.05 vs control. (D) The target relationship between MEG3 and miR-424-5p was predicted and proved. *P<0.05 vs control (E) The effect of downregulation MEG3 by si-MEG3 was proved significant. *P<0.05 vs control. (F) MEG3 knockdown correlated with higher miR-424-5p expression. *P<0.05 vs control. (G) MEG3 knockdown correlated with lower Sema3A expression. *P<0.05 vs control.