Table 3. Association between sarcopenia-related traits and CAD using MR-PRESSO analysis.
| Exposures | Outcomes | IVs selection a | No. of IVs | MR-PRESSO | ||
| OR (95% CI) | p | IVs outliers | ||||
| Body lean mass | CAD | All | 399 | 0.919 (0.834, 1.012) | 0.0866 | rs11065979, rs216193, rs2289976, rs2678204, rs28391281, rs3843751, rs66922415, rs7097872, rs7781964 |
| Removed 1 | 398 | 0.996 (0.986, 1.007) | 0.494 | rs11065979, rs216193, rs2289976, rs2678204, rs28391281, rs3843751, rs66922415, rs7097872, rs7781964 | ||
| Removed 2 | 387 | 0.894 (0.808, 0.989) | 0.030 | rs11065979, rs216193, rs2678204, rs28391281, rs3843751, rs66922415, rs7097872 | ||
| Left handgrip strength | CAD | All | 81 | 0.663 (0.521, 0.843) | 0.001* | rs11130333 |
| Removed 1 | 79 | 0.669 (0.526, 0.852) | 0.002* | rs11130333 | ||
| Removed 2 | 76 | 0.672 (0.523, 0.865) | 0.003* | rs11130333 | ||
| Right handgrip strength | CAD | All | 95 | 0.599 (0.476, 0.753) | 2.9E-05* | No significant outliers |
| Removed 1 | 93 | 0.606 (0.482, 0.762) | 4.3E-05* | No significant outliers | ||
| Removed 2 | 91 | 0.604 (0.477, 0.765) | 6.81E-05* | No significant outliers | ||
| CAD | Body lean mass | All | 39 | 0.997 (0.986, 1.008) | 0.575 | rs10840293, rs11065979, rs11191416, rs17087335, rs2681472, rs3918226, rs56289821, rs663129, rs7528419 |
| Removed 1 | 36 | 0.995 (0.99, 1) | 0.381 | rs10840293, rs11065979, rs11191416, rs17087335, rs2681472, rs3918226, rs56289821, rs663129, rs7528419 | ||
| CAD | Left handgrip strength | All | 39 | 0.992 (0.983, 1) | 0.052 | rs2519093, rs663129, rs9349379 |
| Removed 1 | 36 | 0.991 (0.987, 0.995) | 0.049 | rs2519093, rs663129, rs9349379 | ||
| CAD | Right handgrip strength | All | 39 | 0.992 (0.983, 1) | 0.064 | rs2519093, rs663129, rs9349379 |
| Removed 1 | 36 | 0.991 (0.987, 0.995) | 0.058 | rs2519093, rs663129, rs9349379 | ||
MR-PRESSO analysis was only carried out for associations with a significant global test p value (p < 0.05).
a‘All’ represents analyses with all selected IVs; ‘Removed 1’ represents analyses after removing proxy IVs; ‘Removed 2’ represents analyses after removing potential pleiotropic SNPs (related to body fat mass and height).
Bonferroni corrected significance level (0.05/3 = 0.016) was used to correct for multiple comparisons.
*p<0.016.
CAD: coronary artery disease; MR-PRESSO: Mendelian Randomization Pleiotropy RESidual Sum and Outlier; IVs: instrumental variables; CI: confidence interval; OR: odds ratio.