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. 2020 Feb 12;12(4):3266–3286. doi: 10.18632/aging.102809

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Copyright © 2020 Angenendt et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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mRNA and protein levels of distinct STIM and Orai isoforms are reduced in CD8⁺ T cells of elderly mice. (A) Normalised relative mRNA expressions of Orai1, 2 and 3 and STIM1 and 2 of untouched CD8⁺ T cells from adult (grey, n = 12) and elderly (red, n = 11) mice. (C) Normalised relative mRNA expressions of SOCE components of stimulated CD8⁺ T cells from adult (grey, n = 12) and elderly (red, n = 11) mice. Protein quantification after normalization to GAPDH of SOCE components from (B) untouched (n = 7 - 9) and (D) stimulated (n = 5 - 7) CD8⁺ T cells lysates isolated from adult (black) and elderly (red) mice. Data obtained are presented as mean ± SD. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.