Table 2. Risk of various outcomes in ADPKD patients compared to controls.
| Variable | Inpatient database1 | Catastrophic illness patients2 | ||
| With ADPKD | Control | With ADPKD | Control | |
| N | 4310 | 21550 | 651 | 3255 |
| Person-years | 16373 | 121626 | 2540 | 14774 |
| All-cause mortality | ||||
| Event no | 431 | 1250 | 15 | 53 |
| Incidence density | 26.32 | 10.28 | 5.90 | 3.59 |
| Crude HR (95% CI) | 2.54 (2.27-2.83)*** | Ref. | 1.78 (0.99-3.17) | Ref. |
| Adjusted HR (95% CI) | 2.47 (2.19-2.78)*** | Ref. | 1.71 (0.84-3.48) | Ref. |
| Ischemic stroke | ||||
| Event no | 252 | 1090 | 7 | 49 |
| Incidence density | 15.39 | 8.96 | 2.76 | 3.32 |
| Crude HR (95% CI) | 1.69 (1.47-1.94)*** | Ref. | 0.85 (0.38-1.87) | Ref. |
| Adjusted HR (95% CI) | 1.56 (1.35-1.81)*** | Ref. | 0.49 (0.20-1.22) | Ref. |
| Hemorrhagic stroke | ||||
| Event no | 81 | 207 | 14 | 8 |
| Incidence density | 4.95 | 1.70 | 5.51 | 0.54 |
| Crude HR (95% CI) | 2.87 (2.22-3.72)*** | Ref. | 9.83 (4.12-23.5)*** | Ref. |
| Adjusted HR (95% CI) | 3.19 (2.41-4.22)*** | Ref. | 4.41 (1.41-13.8)* | Ref. |
| ESRD | ||||
| Event no | 1084 | 144 | 116 | 5 |
| Incidence density | 66.21 | 1.18 | 45.66 | 0.34 |
| Crude HR (95% CI) | 49.1 (41.3-58.5)*** | Ref. | 132 (54.0-324)*** | Ref. |
| Adjusted HR (95% CI) | 33.1 (27.6-39.8)*** | Ref. | 56.4 (21.4-146)*** | Ref. |
1Adjusted for age, gender, geography, and all comorbidity using extended Cox proportional hazard regression.
2Adjusted for age, gender, geography, all comorbidity, and medications using Cox proportional hazard regression.
* p<0.05, *** p<0.001.