Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Schematic showing the possible molecular mechanism underlying the effect of AK045171 in TAC- and Ang II-induced cardiac hypertrophy. AK045171 binds with SP1 and activates MG53 transcription. MG53 inhibits nuclear transfer of p65 and β-catenin, thereby decreasing expression of their downstream target genes, such as ANP, BNP and β-MHC.
