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. 2011 Sep 7;2011(9):CD001544. doi: 10.1002/14651858.CD001544.pub4

Moral 2009.

Methods Randomisation: sealed envelops.
Blinding: not described.
Withdrawal/Dropout: not described.
Follow‐up: 30 days after surgery.
Participants Inclusion criteria: elective colorectal surgery with primary anastomosis.
Exclusion criteria: colorectal cancer smaller than 2 cm not marked by colonoscopy, those who were found to have an abscess of the tumour, diverticulitis, patients who refused to be randomised.
Diseases: benign and malign colorectal diseases.
Number: 139 (50 male; 89 female).
Age: 68 ‐ 70 years.
Location: Barcelona, Spain
Time: May 2005 ‐ Agost 2007.
Antibiotics:
‐ Oral (single dose 24 hours before the surgery): neomycin + metronidazole;
‐ Parenteral (single dose at the induction of anaesthesia): ceftriaxone + metronidazole.
Interventions Group A ‐ MBP (n = 69): monobasic sodium phosphate + dibasic sodium phosphate or polyethylene glycol
Group B ‐ no MBP (n = 70): 2 cleansing enemas
‐ the day before the surgery (at 21:00 PM),
‐ 2 hours before the surgery.
Outcomes Overall anastomotic leakage: Group A = 5; Group B = 4
‐ colorectal anastomosis: Group A = 0 (in 31 patients); Group B = 3 (in 19 patients),
‐ colonic anastomosis: Group A = 5 (in 38 patients); Group B = 1 (in 51 patients).
Mortality: Group A = 2; Group B = 0;
Overall wound infection: Group A = 8; Group B = 4
‐ colorectal surgery: Group A = 3 (in 31 patients); Group B = 0 (in 19 patients),
‐ colonic surgery: Group A = 5 (in 38 patients); Group B = 4 (in 51 patients).
Notes Sample size was calculated.
Colonic anastomosis: Group A = 38; Group B = 51;
Colorectal anastomosis: Group A = 31; Group B = 19.
Risk of bias
Bias Authors' judgement Support for judgement
Allocation concealment (selection bias) Low risk A ‐ Adequate