Table 1. .
Patients and treatment characteristics (n = 216) of skull-base and head and neck tumours treated with pencil beam scanning proton therapy
| Parameter | Total N = 216 (%) |
|---|---|
| Patient characteristics | |
| Age at PT (Years) | |
| Median (IQR) | 47 (35.8–60) |
| Gender | |
| Male (%) | 105 (48.6) |
| Female (%) | 111 (51.4) |
| Age ≥ 70 years | |
| Yes (%) | 8 (3.7) |
| No (%) | 208 (96.3) |
| Diabetes | |
| Yes (%) | 17 (7.9) |
| No (%) | 176 (81.5) |
| Unknown | 23 (10.6) |
| Arterial hypertension | |
| Yes (%) | 51 (23.6) |
| No (%) | 142 (65.8) |
| Unknown | 23 (10.6) |
| Hypercholesterolemia | |
| Yes (%) | 16 (7.4) |
| No (%) | 177 (81.9) |
| Unknown | 23 (10.7) |
| Smoking history | |
| Yes (%) | 49 (22.7) |
| No (%) | 120 (55.6) |
| Unknown | 47 (21.7) |
| Visual deficit at start of PT | |
| Yes (%) | 44 (20.3) |
| No (%) | 167 (77.3) |
| Unknown | 5 (2.3) |
| Tumour characteristics | |
| Histology (n = 215) | |
| Chordoma (%) | 114 (52.8) |
| Chondrosarcoma (%) | 48 (22.2) |
| Meningioma WHO G1-3 (%) | 39 (18.1) |
| Adenoid cystic carcinoma (%) | 7 (3.2) |
| Pituitary gland tumours (%) | 2 (0.9) |
| Other (%) | 6 (2.8) |
| GTV (cm3) | |
| Median | 25.9 |
| (range) | (1.8–205.3) |
| Tumour involvement with optic pathways (at beginning of PT) | |
| Yes (%) | 68 (31.5) |
| No (%) | 148 (68.5) |
| Treatment characteristics | |
| PT | |
| Adjuvant (%) | 164 (75.9) |
| Salvaged (%) | 52 (24.1) |
| Median administered dose (range) [GyRBE] | |
| D max ON (range) [GyRBE] | 59.5 (18–76.1) |
| D mean ON (range) [GyRBE] | 35.5 (1.7–67.8) |
| V45 ON (range) [ml] | 0.43 (0–1.8) |
| V60 ON (range) [ml] | 0 (0–1.14) |
| D max OC(range) [GyRBE] | 58.8 (37.6–66.5) |
| D mean OC (range) [GyRBE] | 50.5 (3.7–62.6) |
| V45 OC (range) [ml] | 0.85 (0–2.4) |
| V60 OC (range) [ml] | 0 (0–1.3) |
GTV, gross tumour volume; IQR, interquartile range; OC, optic chiasma; ON, optic nerve; PT, proton therapy; RBE, relative biological effectiveness.