Table 2. .
RION observed in 14 skull base and head and neck tumours patients after pencil beam scanning proton therapy
| Toxicity # | Tumour type | ON D max (Gy RBE) |
ON D mean (Gy RBE) |
OC D max (Gy RBE) |
OC D mean (Gy RBE) |
Tumour abutting ON (yes/no) |
HTA (yes/no) |
Time to RION (months) |
Grade RION | RION (Uni/Bilat) |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Chordoma | 57.9 | 30.5 | 60.2 | 56.7 | No | Yes | 18.1 | 4 | Uni |
| 2 | Chordoma | 59.8 | 19.2 | 55.6 | 50.3 | No | Yes | 8.7 | 4 | Uni |
| 3 | Chordoma | 62.5 | 55.1 | 61.0 | 59.4 | Yes | Yes | 24.3 | R2; L1 | Bilat |
| 4 | Chordoma | 60.1 | 54.7 | 60.0 | 54.8 | Yes | No | 4.8 | 1 | Uni |
| 5 | Chordoma | 63.2 | 37.6 | 60.0 | 53.4 | No | Yes | 13.1 | 4 | Uni |
| 6 | Chordoma | 60.2 | 30.5 | 60.0 | 53.9 | No | No | 9.3 | R4; L4 | Bilat |
| 7 | Chordoma | 60.3 | 28.1 | 60.2 | 52.1 | No | Yes | 14.2 | 3 | Uni |
| 8 | Chondrosarcoma | 60.6 | 38.4 | 60.6 | 57.1 | Yes | Yes | 42.6 | 4 | Uni |
| 9 | Meningioma | 56.3 | 35.4 | 56.5 | 48.4 | Yes | No | 8.2 | 4 | Uni |
| 10 | Meningioma | 66.9 | 55.0 | 64.1 | 62.6 | Yes | No | 5.9 | 4 | Uni |
| 11 | Meningioma | 53.3 | 42.5 | 53.7 | 49.4 | No | Yes | 13.4 | 3 | Uni |
| 12 | ACC | 60.3 | 57.1 | 56.2 | 47.0 | Yes | Yes | 5.6 | R4; L2 | Bilat |
| 13 | ACC | 57.8 | 52.6 | 58.2 | 48.8 | No | Yes | 19.1 | 4 | Uni |
| 14 | Pituitary gland adenoma | 57.8 | 45.4 | 53.3 | 45.7 | Yes | Yes | 32.5 | 4 | Uni |
D mean: Mean dose; ACC: adenocystic carcinoma; Bilat: bilateral;Dmax: maximum dose; HTA: arterial hypertension; L: left eye; OC: optic chiasma; ON: optic nerve; R: right eye; RION: radiation-induced optic neuropathy; Uni: unilateral.