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. Author manuscript; available in PMC: 2020 May 22.
Published in final edited form as: ACS Appl Mater Interfaces. 2019 May 13;11(20):18074–18089. doi: 10.1021/acsami.9b01343

Figure 5.

Figure 5.

Cell internalization mechanism of Pro-Nifuroxazide NPs. (A) Inhibitor pre-incubation study performed on MCF-7 cells after Pro-Nifuroxazide treatment at 20, 10 and 5 μM concentration of Nifuroxazide or Pro-Nifuroxazide NPs alone. (B-D) Cell TEM performed on I-Pro-nifuroxazide NPs) after 30 min of incubation showing position of membrane fusion as mode of cellular entry. Cell incubated with rhodamine alone (E, F) and Rh-Pro-nifuroxazide NPs (G, H). Here E and G represent DAPI stained cellular nucleus while F and H shows Rh distributed in intracellular space. Cells were incubated with rhodamine and Rh-Pro-nifuroxazide NPs for 4h. Here * represents p values <0.05 and 0.001, respectively.