Figure 3. Microbiological and histopathological evaluation of heart valves removed from patient with endocarditis. PCR: Polymerase chain reaction; rRNA: Ribosomal RNA; * Periodic-acid Schiff (PAS)-positive staining reaction is seen in the macrophages infected with Tropheryma whipplei; ** For example, Mycoplasma hominis, Legionella spp., Chlamydia spp., Cutibacterium (formerly Propionibacterium) acnes, etc.