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(A) Bar chart depicting numbers of patients (y-axis) expressing specific tumor mutational burden values (x-axis). (B) Representative immunohistochemical micrographs demonstrating low (ii), intermediate (iii), and high (iv) PD-L1 staining and high (vi) PD-1 staining in PCNSL cases with negative controls for PD-L1 (i) and PD-1 (v), respectively. Bar = 1 mm at 20× magnification. (C) Bar chart demonstrating the frequency of expression of immune checkpoint biomarkers in PCNSLs.
