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. 2020 Mar 2;16(3):e1007147. doi: 10.1371/journal.pcbi.1007147

Fig 1. The pathway model and experimental data.

Fig 1

A: Illustration of the EGFR/MET signaling pathway, focusing on the ERK and AKT signaling cascades, used to build the mathematical model. B: Illustration of the mathematical model indicating shared and cell-line specific biochemical species/reactions. C-D: Overview of the experimental data used for model calibration for MKN1 and Hs746T cell lines. The amount of data from the literature (published by [9]) and newly collected data (published as part of this study) is distinguished.