Fig 1. Study of co-evolution in artificial allosteric networks.

A: Example of an elastic network made of harmonic springs (red) evolved in silico to maximize the cooperativity between the allosteric site (purple) and the active site (blue). The response to binding at the allosteric site is indicated by black arrows, and is found to follow a shear motion. B: Each network corresponds to a sequence of 0 and 1 coding for the spring absence or presence. Our scheme allows us to generate a large number M of such sequences, each corresponding to a slightly different shear architecture.