Table 3.

Overlap of mutated genes between canine hemangiosarcoma and human angiosarcoma tumors in several gene families and pathways. Significantly mutated genes bolded.

Gene family	Human only	Shared	Canine only
Phosphatidyl- inositol signaling KEGG Pathway	DGKB, DGKD, DGKQ, IMPA2, INPP4B, ITPR1, ITPR2, ITPR3, PI4KA, PIK3CG, PIK3R2, PIP5K1B, PLCB1, PRKCB	DGKI, PIK3C2G,PIK3CA, PLCB2, PLCB3, PLCG1, PLCG2, PTEN	DGKG, PIK3C3, PIK3CB, PIK3R1, PIK3R5, PLCB4, PLCE1
Phospholipase C	PLCB1, PLCH1, PLCXD1, PLCXD3	PLCB2, PLCB3, PLCG1, PLCG2	PLCB4, PLCE1
Protein tyrosine phosphatase	PTP4A2, PTPN7, PTPN9, PTPN13, PTPN23, PTPRA, PTPRB, PTPRC, PTPRH, PTPRO, PTPRQ, PTPRR, PTPRS, PTPRT	PTPN5, PTPN22, PTPRD, PTPRJ, PTPRK, PTPRZ1	PTP4A1, PTPDC1, PTPN4
LDL receptor related proteins	LRP3	LRP1, LRP1B, LRP2, LRP4
Histone methyltransferase/demethylase activity GO terms	EHMT2, KDM4A, KDM4B, KDM4D, KDM5C, KDM6B, KMT2B, KMT2C, NSD1, PHF2, PRDM16, PRDM7, PRDM9, SETD2, SETDB1, SETDB2	KDM5A, KMT2D, MECOM	JMJD1C, KDM3A, KMT2A, PRMT2
MAPK signaling pathway KEGG Pathway	AKT3, ARRB1, CACNA1A, CACNA1B, CACNA1G, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNB1, CACNB3, CACNG3, CHP2, CHUK, DUSP4, EGF, FGF7, FGF12, FGFR2, FLNC, GRB2, HRAS, HSPA1L, MAP2K3, MAP3K4, MAP3K5, MAP3K11, MAP4K1, MAP4K3, MAP4K4, MAPK10, MAPK8IP3, MOS, MYC, NF1, NTRK1, NTRK2, PAK2, PDGFRA, PDGFRB, PPP3CA, PRKCB, PTPN7, PTPRR, RAF1, RAPGEF2, RASGRF2, RASGRP3, RPS6KA1, RPS6KA5, RPS6KA6, TAOK1, TGFB2	BRAF, CACNA1D, CACNA1E, CACNA1H, CACNB2, FGFR3, MECOM, NRAS, PLA2G4A, PTPN5, RASA1, SOS2, TP53	CACNA1C, IL1B, MAP3K6, MAP3K13, NFATC4, PLA2G4E, PPM1B, RASGRF1, RASGRP1, RPS6KA3, SOS1, STK4
Protein tyrosine kinase activity GO terms	ALK, BLK, CLK2, CLK3, DDR1, DDR2, DSTYK, EGF, EPHA2, EPHA3, EPHA4, EPHA6, EPHB4, EPHB6, ERBB2, ERBB3, FGF7, FGFR2, FLT4, FRK, HSP90AA1, KIT, MAP2K3, MATK, MERTK, NTRK1, NTRK2, PDGFRA, PDGFRB, PKDCC, PTK2B, RET, ROR2, ROS1, SGK223, SRMS, STYK1, SYK, TEC, TTK, TYRO3, ZAP70	EPHA5, EPHA7, ERBB4, FGFR3, FLT3, IGF1R, JAK1, KDR, NTRK3, PTK2, TIE1, TTN	CDC37, EFNB3, EPHB2, FYN, IL3RA, NRG1, NRP1, STAT5A, TEK, TYK2