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Schematic of 2C4K. Cp is plasma compartment, representing unmetabolized 18F-FGln that is available for transport across vasculature into tissue. First compartment represents nonspecifically bound 18F-fluoroglutamine that has been transported into tumor cells by ASCT2 and other transporters, whereas second compartment represents activity from 18F-fluoroglutamate (18F-FGlu), produced in first and rate-limiting step of glutaminolysis that is catalyzed by glutaminase.
