TABLE 6.
Mean Intratumor Values for Metrics Derived from Early-Response 18F-FGln Dynamic PET Scans with 2C4K Model
| Metric | All lesions (n = 8) | Corresponding 8 lesions on baseline |
| SUV1 | 3.5 ± 1.5 (2.0–7.1) | 3.2 ± 1.5 (1.8–6.3) |
| SUV2 | 3.0 ± 1.2 (2.0–5.7) | 2.8 ± 1.1 (1.5–4.8) |
| vB | 0.17 ± 0.10 (0.03–0.30) | 0.12 ± 0.06 (0.04–0.19) |
| K1 (mL/min/g) | 0.21 ± 0.16 (0.04–0.46) | 0.23 ± 0.12 (0.07–0.43) |
| k2 (min−1) | 0.09 ± 0.04 (0.03–0.13) | 0.15 ± 0.10 (0.04–0.30) |
| k3 (min−1) | 0.05 ± 0.06 (0.00–0.14) | 0.09 ± 0.09 (0.00–0.23) |
| k4 (min−1) | 0.03 ± 0.03 (0.00–0.10) | 0.02 ± 0.02 (0.00–0.06) |
| VT (mL/cm3) | 3.4 ± 1.5 (1.3–5.6) | 4.7 ± 2.2 (2.2–9.1) |
SUV1 and SUV2 are SUV, corrected by body weight, as calculated from last 5-min frame of 30-min dynamic PET acquisition and from ∼100-min PET acquisition, respectively. SUV3 is not reported because only 2 patients had ∼190-min postinjection acquisitions on both first and second 18F-FGln dynamic PET. Data are mean ± SD, followed by range in parentheses.
vB = pharmacokinetic model with blood fraction component.