TABLE 3.

Diagnostic Accuracy of ¹⁸F-NaF PET/CT in 211 Patients with Final Diagnosis for Presence or Absence of Bone Metastases

	M0 by final diagnosis (n = 147)			M1 by final diagnosis (n = 64)			Sensitivity	Specificity	PPV	NPV
Scale	M0	Equivocal	M1	M0	Equivocal	M1
3-category
Observer 1	136	7	4	5	4	55	0.86 (0.75–0.93)	0.97 (0.93–0.99)	0.93 (0.84–0.98)	0.94 (0.89–0.97)
							0.92 (0.83–0.97)	0.93 (0.87–0.96)	0.84 (0.74–0.92)	0.97 (0.92–0.99)
Observer 2	122	21	4	5	2	57	0.89 (0.79–0.96)	0.97 (0.93–0.99)	0.93 (0.84–0.98)	0.95 (0.91–0.98)
							0.92 (0.83–0.97)	0.83 (0.76–0.89)	0.70 (0.59–0.80)	0.96 (0.91–0.99)
Consensus	132	11	4	6	2	56	0.88 (0.77–0.94)	0.97 (0.93–0.99)	0.93 (0.84–0.98)	0.95 (0.90–0.98)
							0.91 (0.81–0.96)	0.90 (0.84–0.94)	0.79 (0.68–0.88)	0.96 (0.91–0.98)
Dichotomous
Observer 1	141		6	7		57	0.89 (0.79–0.96)	0.96 (0.91–0.98)	0.91 (0.80–0.96)	0.95 (0.91–0.98)
Observer 2	137		10	7		57	0.89 (0.79–0.96)	0.93 (0.88–0.97)	0.85 (0.74–0.93)	0.95 (0.91–0.98)
Consensus	142		5	8		56	0.88 (0.77–0.94)	0.97 (0.92–0.99)	0.92 (0.82–0.97)	0.94 (0.90–0.98)

CI = confidence interval; PPV = positive predictive value; NPV = negative predictive value.

Data are for 2 observers (in cases of disagreement, observers reevaluated scans and reached consensus diagnosis) and for optimistic analytic approach (pessimistic approach is in italics). Data in parentheses are 95% confidence intervals.