Table 3.

Associations of Bone Turnover Level^a in Early Postmenopause^b with Incident Fracture in Postmenopause

	HR per SD Increment in Peak Level of U-NTX in Early Postmenopause (95% CI)	P Value
Base modelc	1.27 (1.04-1.54)	.01
+ LS BMD in early postmenopause	1.24 (1.00-1.54)	.03
+ FN BMD in early postmenopause	1.25 (1.00-1.56)	.03

^aBone turnover assessed by U-NTX.

^bEarly postmenopause was operationalized as 2 years following the final menstrual period. The bone turnover assessment was made at the first available visit in early postmenopause.

^cBase model controlled for the following covariates obtained in early postmenopause: age, body mass index, race/ethnicity, fracture before the MT, current cigarette use (yes/no), and Study of Women’s Health Across the Nation study site.

BMD, bone mineral density; CI, confidence interval; FN, femoral neck; HR, hazard ratio; LS, lumbar spine; U-NTX, urinary collagen type I N-telopeptide.