Table 4.

Contributions of Fast Increase in Bone Turnover^a During the Menopause Transition (MT)^b versus High Bone Turnover Level in Early Postmenopause as Predictors of Incident Fracture in Postmenopause

	Relative Fracture Hazardd (95% CI)	P Value
Fast MT increase and low early postmenopausal peake	1.54 (0.68-3.47)	.2
Slow MT increase and high early postmenopausal peake	1.04 (0.43-2.50)	.8
Fast MT increase and high early postmenopausal peake	1.80 (1.00-3.22)	.04

^aBone turnover assessed by urinary collagen type I N-telopeptide (U-NTX).

^bThe MT was operationalized at 2 years before to 2 years after the final menstrual period, corresponding to when bone turnover increases most rapidly.

^cEarly postmenopause was operationalized as 2 years following the final menstrual period (corresponding to when U-NTX reaches its peak and plateaus). The bone turnover assessment was obtained at the first available visit in early postmenopause.

^dHazard for fracture compared with women with slow increase in bone turnover during the MT and low bone turnover in early postmenopause. Slow vs. fast increase in bone turnover during the MT was defined as a rate of increase in U-NTX during the MT that was less vs. more than the sample median (+2.9 nM BCE/nmM Cr per year). Low vs. high bone turnover level in early postmenopause was defined as an U-NTX level (obtained at the first available visit in early postmenopause) that was less vs. more than the sample median (45.6 nM BCE/mM Cr).

^eAll models adjusted for race/ethnicity and SWAN study site.

CI, confidence interval.