Appendix 1—table 1. UK Biobank phenotype data used in this study and their corresponding data fields.
In parentheses are the units of measurements.
| Trait | Description | UKB data field |
|---|---|---|
| Age | Age when attended assessment center (years) | 21003 |
| Age at first sex | Self-reported age at first sexual intercourse (years) | 2139 |
| Alcohol intake frequency | Self-reported category, encoded as an integer: 1, 'Daily or almost daily’; 2, 'Three or four times a week’; 3, 'Once or twice a week’; 4, 'One to three times a month’; 5, 'Special occasions only’; 6, 'Never’ | 1558 |
| Basal metabolic rate | Estimated from body composition impedance measurements (KJ) | 23105 |
| Birth weight | Self-reported birth weight (Kg) | 20022 |
| Body mass index | Constructed from height and weight measurements (Kg/m2) | 21001 |
| Diastolic blood pressure | Measured using automated devices (mmHg); values are adjusted for medicine use (see Materials and methods) | 4079, 6153, 6177 |
| Fluid intelligence | Unweighted sum of the number of correct answers given to 13 fluid intelligence questions | 20016 |
| Forced vital capacity | Calculated from breath spirometry (liters) | 3062 |
| Hair color | Self-reported category, encoded as an integer: 1, 'Blonde’; 2, 'Red’; 3, 'Light brown’; 4, 'Dark brown’; 5, 'Black’; none, 'Other’ | 1747 |
| Hand grip strength | Measured right and left hand isometric grip strength (Kg) | 46, 47 |
| Height | Measured standing height (cm) | 50 |
| Hip circumference | Measured hip circumference (cm) | 49 |
| Hospital inpatient diagnoses | Diagnoses made during hospital inpatient admissions, coded according to the International Classification of Diseases (ICD-9 and ICD-10) | 41202, 41203, 41204, 41205, 41270, 41271 |
| Household income | Self-reported average total annual household income before tax category, encoded as an integer: 1, 'Less than £18,000'; 2, '£18,000 to £30,999'; 3, '£31,000 to £51,999'; 4, '£52,000 to £100,000'; 5, 'Greater than £100,000' | 738 |
| Myocardial infarction outcomes | Algorithmically-defined myocardial infarction outcomes obtained through combinations of UK Biobank's assessment data collection (e.g., self-reported conditions), and data from hospital admissions | 42000, 42001 |
| Neuroticism score | Derived summary score, based on participants’ responses to 12 neurotic behaviour-related questions | 20127 |
| Number of full siblings | Sum of self-reported number of full brothers and full sisters | 1873, 1883 |
| Overall health rating | Self-reported category, encoded as an integer: 1, 'Excellent'; 2, 'Good'; 3, 'Fair'; 4, 'Poor’ | 2178 |
| Pack years of smoking | Calculated for individuals who have ever smoked as the number of cigarettes smoked per day, divided by twenty, multiplied by the number of years of smoking (years) | 20161 |
| Pulse rate | Measured during the automated blood pressure readings (bpm) | 102 |
| Qualifications | Self-reported educational or professional qualifications, selected from: 'College or University degree', 'NVQ or HND or HNC or equivalent', 'Other professional qualifications eg: nursing, teaching', 'A levels/AS levels or equivalent', 'O levels/GCSEs or equivalent', 'CSEs or equivalent', or 'None of the above' | 6138 |
| Sex | Self-reported sex and as determined from genotyping analysis | 31, 22001 |
| Skin color | Self-reported category, encoded as an integer: 1, 'Very fair'; 2, 'Fair'; 3, 'Light olive'; 4, 'Dark olive'; 5, 'Brown'; 6, 'Black' | 1717 |
| Townsend deprivation index | Townsend deprivation index at recruitment | 189 |
| Vascular/heart problems | Self-reported vascular/heart problems diagnosed by doctor selected from the categories: 'Heart attack’, 'Angina', 'Stroke', 'High blood pressure', and 'None of the above' | 6150 |
| Waist circumference | Measured waist circumference (cm) | 48 |