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. Author manuscript; available in PMC: 2021 Mar 30.
Published in final edited form as: Int J Pharm. 2020 Jan 29;578:119090. doi: 10.1016/j.ijpharm.2020.119090

Figure 9:

Figure 9:

Effect of NL-1 and NL-1 nanoparticles on apoptosis in bEnd.3 cells following ischemia and reperfusion. Figures A-D are representative flow cytometry data for cell blank (A), 3 hour OGD (B), and 3 hour OGD with NL-1 (C) and 3 hour OGD with NL-1 nanoparticles (D). Each figure shows four quadrants: live (bottom left), early apoptotic phase (bottom right), late apoptotic phase (top right), and necrotic (top left) cell populations. Results are indicated in terms of improvement in cell survival at 3 hours (E) and 6 hours (F) ischemic period, as well as the reduction in late stage apoptosis after 3 hours (G) and 6 hours (H) of ischemia (*p<0.05, **p<0.01, ***p<0.001, ****p<0.0001).