Table 1:

Major Barriers Impeding Translation of Hypertension Research

Communication gaps among basic science researchers, clinical researchers, and clinicians in the field of hypertension are preventing translation of fundamental discoveries to better BP control.

Limited understanding of the antecedents of hypertension such as fetal programming and epigenetics.

Limited understanding of gene-environment and gene-gene interactions to improve therapeutic decision making in hypertension.

While animal models are crucial for identifying therapeutic targets and testing new drugs, not all experimental and genetic animal models are applicable to humans.

Poor understanding and validation of methods for detection and reversal of antihypertensive medication non-adherence.

Limited understanding of age-related changes in BP in children, adolescents and young adults, determinants of BP for early prevention and effectiveness of antihypertensive therapy to improve clinical outcomes.

Insufficient engagement of diverse stakeholders such as payers and insurers through all study phases to enhance uptake and feasibility of clinical trials and clinical trial findings.

Insufficient knowledge of how efficacious community-based interventions can be brought to scale