Fig. 1. On-grid cell culture set up and confocal imaging for on-grid validation.
(A) Bright-field image of MDA-MB231 cells seeded on a fibronectin-functionalized carbon-coated gold TEM grid in a cell culture dish (arrow represents location of cells on the suspended fibronectin-coated carbon support film). (B) Bright-field image and (C) fluorescence confocal image of MDA-MB231 cells grown uniformly on the grid, including in the electron-transparent grid squares. Blue – DAPI (nuclei), green-Phalloidin Alexa Fluor 488 (F-actin).