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. 2020 Mar 6;11:149. doi: 10.3389/fneur.2020.00149

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Copyright © 2020 Abdullah, Crawford, Tsolaki, Börjesson-Hanson, Olde Rikkert, Pasquier, Wallin, Kennelly, Ait-Ghezala, Paris, Hendrix, Blennow, Lawlor and Mullan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cerebrospinal fluid Aβ biomarkers. Ratios of CSF Aβ42/Aβ40 increase in nilvadipine-treated mild AD but decrease in moderate AD patients compared to their respective placebo groups. (Mean ± SE n = 9 for moderate AD on nilvadipine, n = 12 for moderate AD on placebo, n = 14 for mild AD on nilvadipine, n = 20 for mild AD on placebo). (A) Ratios of Aβ42/Aβ40 were higher in mild AD treated with nilvadipine compared to those treated with placebo (p = 0.067). There was a significant decrease in Aβ42/Aβ40 in moderate AD treated with nilvadipine compared to placebo. Also in moderate AD subjects, levels of (B) Aβ38 and (C) Aβ40 were elevated and (D) Aβ42 levels were unchanged in moderate AD subjects treated with nilvadipine. Levels of Aβ42 were non-significantly higher in mild AD treated with nilvadipine. *p < 0.05.