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. 2020 Mar 12;10:4561. doi: 10.1038/s41598-020-61443-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Aged mice fed a short-term HFD with concomitant administration of exogenous rGDF11, but not rGDF8, show a transient reduction in food intake. (A,B) Body composition of young (A, n = 4–6 mice/treatment) and aged (B, n = 5–6 mice/treatment) mice before (pre) and 7 days after (post) concomittant HFD feeding and administration of saline (black), rGDF11 (orange), or rGDF8 (blue). Fat and lean mass values shown on the left and percent of body weight (BW) shown on the right. (C–F) Total daily food intake (C,D) and activity (E,F) were measured from young (C,E, n = 4–6 mice/treatment) and aged (D,F, n = 5–6 mice/treatment) mice before (pre) and 7 days after (post) concomittant HFD feeding and administration of saline (black), rGDF11 (orange), or rGDF8 (blue). Data information: In (A–F), data are presented as mean ± standard deviation. For (A–F), 2-way ANOVA with Tukey’s post hoc test was used for all comparisons.