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. 2020 Mar 12;6:13. doi: 10.1038/s41420-020-0247-6

Fig. 2. microRNAs with anti-apoptotic functions and relative inhibited molecular pathways.

Fig. 2

a miR-21 is the most upregulated oncomiR in solid tumors and hematological malignancies. The oncogenic activity of miR-21 is associated with the direct negative regulation of pro-apoptotic genes, such as APAF11, PDCD4, RHOB, and FASLG. b miR-155 plays a key role in the regulation of the immune response. miR-155 is upregulated in B-cell lymphomas and by targeting SHIP-1 supports cell survival. c In liver cancer, miR-221 exerts oncogenic activity by repressing the expression of the apoptotic proteins PUMA and BIM. APAF11 apoptotic protease activating factor 1, PDCD4 programmed cell death protein 4, RHOB Ras Homolog Family Member B, FASLG Fas ligand, SHIP-1 Src homology 2-SH2 domain containing inositol polyphosphate 5-phosphatase 1, PUMA p53 upregulated modulator of apoptosis, BIM BCL-2-like protein 11.