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. 2020 Mar 12;6:13. doi: 10.1038/s41420-020-0247-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a CCAT is an oncogene that protects from cell death by up-regulating the expression of MYC. b p63, SOX2, and CCAT form a trimeric complex, which in turn binds the promoter region of EGFR and positively upregulates its expression. This results in sustaining cell survival. c FAL1 associates with the epigenetic repressor BMI1 and regulates its stability in order to modulate the transcription of a number of genes involved in cell death. CCAT colon cancer-associated transcript, MYC Myc proto-oncogene, SOX2 sex determining region box-2, EGFR epithelial growth factor receptor, FAL1 focally amplified LncRNA on chromosome 1, BMI1 polycomb complex protein BMI1.