Figure 2.

Performance comparison of forecASD with competing methods in prioritizing genes hit by recurrent de novo loss-of-function mutations across three independent ASD cohorts. Bar height and color indicate the fraction of genes with recurrent LOF mutations (n = 44) within the given decile of genes ranked by each score. A binomial test was used to assess for an enrichment of genes with recurrent LOF mutations in the top decile of each score, using each scores decile enrichment for proband synonymous mutations as a baseline (result listed in parentheses below score name).