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. 2020 Mar 12;10:4569. doi: 10.1038/s41598-020-61288-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Clustering of genes highlighted by forecASD into distinct modules. Greedy hierarchical optimization of the modularity score yielded 17 clusters consisting of 1,452 forecASD genes (a). All clusters have several significantly enriched biological pathways, of which the top terms were labeled. Clusters were tested for significance of overlap with the list of SFARI HC genes (b), and enrichment of haploinsufficiency genes (pLI > 0.5; c).