Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Mar 12;9(3):34. doi: 10.1038/s41389-020-0217-0

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 7 — Tumors of PDTX models derived from p53 wild-type samples of six patients were intratumorally injected with LNA-PIK3CD-AS2 or scramble control twice weekly for four weeks. The mice were killed and analyzed four weeks after LNA administration. a Representative images of mice (top) and xenograft tumors (bottom) were shown. n = 6. b, c Tumor volume (b), and tumor weights (c) were quantitative analyzed. Data are shown as means ± SD. Statistical analysis was performed using unpaired t-test. *P < 0.05; **P < 0.01. d, e Xenograft tumor sections were measured for H&E staining and the expression of Ki67, TUNEL (d), YBX1, p-YBX1 and p53 (e). f Kaplan–Meier analysis of disease-free survival curve of p53 wild-type LUAD patients in TCGA datasets based on PIK3CD-AS2 expression (log rank test, P = 0.011).