Table 3.

DTI findings in ALS patients and controls [fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD)].

	FA values			FA values + covariate A*	FA values + covariate B*	MD values		AD values		RD values
ROI	ALS (N = 19)	Controls (N = 20)	p	P	p	ALS (10−4)	p	ALS (x10−3)	p	ALS (x10−4)	p
CST right	0.589	0.624	0.026	0.011	0.093	6.075	0.643	1.057	0.038	3.849	0.068 0.164
CST left	0.621	0.648	0.126	0.020	0.049	5.959	0.760	1.067	0.114	3.624
Genu	0.737	0.731	0.604	0.458	0.470	7.289	0.942	1.507	0.648	3.404	0.714
Body	0.698	0.701	0.875	0.346	0.355	7.700	0.621	1.536	0.445	3.871	0.876
Splenium	0.789	0.786	0.604	0.149	0.102	7.108	0.449	1.569	0.909	2.863	0.578
Crus posterior of internal capsule right	0.700	0.716	0.484	0.972	0.188	6.509	0.066	1.285	0.085	3.338	0.165
Crus posterior of internal capsule left	0.699	0.705	0.668	0.705	0.074	6.519	0.871	2.879	0.833	3.344	0.658

^*Covariate A: ALSFRS-R, amyotrophic lateral sclerosis functional rating scale-revised; covariate B: UMNB, upper motor neuron burden.