Figure 1.

Rs2836411 is marked as an enhancer in HUVECs and aortic tissue. From top to bottom the following tracks are shown: UCSC genes with the ERG-P3 promoter indicated by a hooked arrow; overlaid ENCODE track of ChIP-seq signal for the histone modifications H3K4me1 and H3K27ac for seven different commonly used cell lines (see key for colours corresponding to each cell line); H3K27ac and H3K4me1 ChIP-seq tracks for five different thoracic and ascending aorta tissue samples (obtained from ENCODE); super-enhancer regions in aortic tissue and HUVECs obtained from dbSUPER. The genotypes of rs2836411 for the aortic tissue samples are indicated on the right side of each track. The location of rs2836411 is highlighted and marked by a red arrow. Tracks were obtained using the UCSC genome browser.