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. 2019 Nov 6;29(4):554–565. doi: 10.1093/hmg/ddz256

Figure 4.

Figure 4

rs2836411 interact highly within the ERG super-enhancer in HUVECs and interactions are reduced for the T allele. (A) Hi-C contact map in HUVECs with TADs indicated are aligned with 4C-seq profiles using a restriction fragment containing rs2836411 as a bait in HUVECs and HASMCs harbouring the C allele of rs2836411. H3K4me1 and H3K27ac tracks (ENCODE data; light blue) and the super-enhancer region from dbSUPER (purple) in HUVECs are shown below the 4C-seq profiles. Hi-C data are from Rao et al., 2014 (61) and were obtained using the 3D genome browser (70). (B) 4C-seq profiles for the C (protective) and T (risk) allele of rs2836411 in HUVECs are shown. (A and B) 4C-seq frequency tracks (black) are the read per million normalized running mean of 21 successive MseI restriction fragments for the average of two replicates and are shown together with statistically significant interactions (the top fifth percentile of interactions with a FDR of < 0.01) that overlap between two replicates (red). UCSC reference genes are in blue and ERG P1/2 and P3 promoters are indicated by hooked arrows. Tracks were obtained using the UCSC genome browser.