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Hypothetical model of the functional mechanism by which rs2836411 could act. Rs2836411 is located in an enhancer element that is part of a super-enhancer downstream of ERG-P3. When ERG is expressed, the super-enhancer is active and forms a sub-domain structure. The risk allele (T) of rs2836411 reduces enhancer activity, correlates with reduced ERG expression and might alter interaction strength within the super-enhancer region.
