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. 2020 Mar 12;6(3):e03565. doi: 10.1016/j.heliyon.2020.e03565

Table 3.

Association of rs895819 with GI cancer and subgroups.

Name of Cancer Genotypes & Alleles Crude OR (95%CI) P Value Adjusted ORa (95%CI) Pa Value Adjusted ORb(95% CI) Pb Value
GI cancer AA 1 (Reference) 1 (Reference) 1 (Reference)
AG 0.84 (0.54–1.31) 0.435 1.10 (0.69–1.76) 0.857 1.15 (0.73–1.82) 0.55
GG 1.12 (0.62–2.05) 0.703 0.72 (0.38–1.36) 0.311 0.86 (0.45–1.62) 0.629
Dominant 0.89 (0.58–1.39) 0.595 1 (0.64–1.57) 0.996 1.07 (0.69–1.66) 0.77
Recessive 0.821 (0.49–1.39) 0.463 1.43 (0.85–2.49) 0.202 1.21 (0.71–2.07) 0.494
A 1 (Reference) 1 (Reference) 1 (Reference)
G 1.00 (0.76–1.32) 0.991 0.91 (0.68–1.22) 0.519 0.98 (0.73–1.31) 0.886
GC AA 1 (Reference) 1 (Reference) 1 (Reference)
AG 0.91 (0.50–1.64) 0.743 1.13 (0.58–2.21) 0.722 0.90 (0.49–1.65) 0.736
GG 1.23 (0.56–2.68) 0.604 2.31 (0.9–5.90) 0.082 1.24 (0.53–2.86) 0.622
Dominant 0.91 (0.55–1.7) 0.906 1.31 (0.69–2.48) 0.411 0.97 (0.55–1.73) 0.926
Recessive 0.79 (0.40–1.55) 0.492 0.51 (0.23–1.07) 0.075 0.784 (0.39–1.57) 0.491
A 1 (Reference) 1 (Reference) 1 (Reference)
G 1.05 (0.73–1.52) 0.794 0.74 (0.49–1.12) 0.154 0.948 (0.65–1.38) 0.78
CRC AA 1 (Reference) 1 (Reference) 1 (Reference)
AG 0.63 (0.35–1.15) 0.133 1.43 (0.77–2.64) 0.254 1.44 (0.77–2.67) 0.251
GG 1.24 (0.59–2.62) 0.576 0.66 (0.30–1.47) 0.306 0.641 (0.29–1.42) 0.641
Dominant 0.75 (0.43–1.32) 0.32 1.17 (0.66–2.08) 0.593 1.17 (0.66–2.09) 0.593
Recessive 0.63 (0.33–1.22) 0.174 1.83 (0.92–3.65) 0.84 1.70 (0.86–3.33) 0.126
A 1 (Reference) 1 (Reference) 1 (Reference)
G 1.01 (0.7–1.47) 0.955 0.897 (0.61–1.32) 0.582 0.91 (0.62–1.34) 0.649
EC AA 1 (Reference) 1 (Reference) 1 (Reference)
AG 1.29 (0.37–2.91) 0.613 0.74 (0.27–2.03) 0.56 0.88 (0.32–2.45) 0.805
GG 0.98 (0.23–4.21) 0.982 0.96 (0.21–4.4) 0.961 1.04 (0.23–4.72) 0.956
Dominant 1.22 (0.46–3.23) 0.688 0.77 (0.29–2.05) 0.595 0.93 (0.34–2.5) 0.882
Recessive 0.726 (0.35–4.46) 0.726 0.896 (0.25–3.23) 0.785 0.84 (0.23–3.06) 0.835
A 1 (Reference) 1 (Reference) 1 (Reference)
G 1.02 (0.56–1.87) 0.947 0.925 (0.50–1.70) 0.801 1.02 (0.54–1.91) 0.951
Others AA 1 (Reference) 1 (Reference) 1 (Reference)
AG 1.04 (0.37–2.91) 0.948 0.981 (0.35–2.78) 0.972 1.07 (0.37–3.09) 0.904
GG 0.33 (0.31–0.33) 0.312 3.39 (0.37–31.6) 0.282 2.91 (0.33–25.9) 0.339
Dominant 0.88 (0.32–2.43) 0.807 1.13 (0.40–3.17) 0.816 1.23 (0.43–3.53) 0.698
Recessive 3.23 (0.42–25.05) 0.236 0.323 (.0.4–2.55) 0.283 0.36 (0.45–2.85) 0.332
A 1 (Reference) 1 (Reference) 1 (Reference)
G 0.77 (0.39–1.52) 0.447 1.29 (0.64–2.59) 0.474 1.32 (0.64–2.72) 0.451

ORa, Pa, adjusted for age and sex, ORb, Pb, adjusted for Diabetes mellitus, Diet and Region, GI, Gastrointestinal, GC, gastric cancer, EC, esophageal cancer.