Table 2.
Look-up of RD GWAMA associations in the 23andMe data set
| RD GWAMA | RD 23andMe | |||||||
|---|---|---|---|---|---|---|---|---|
| SNP | Locus | EA | ALT | EAF | OR[CI] | P | OR[CI] | P |
| rs4373767 | 5′ ZC3H11B | T | C | 0.63 | 1.128 [1.086–1.171] | 1.30 × 10−9 | 1.045 [1.014–1.077] | 4.03 × 10 −3 |
| rs74764079 | BMP3 | T | A | 0.97 | 0.717 [0.642–0.802] | 1.20 × 10−11 | 0.825 [0.755–0.901] | 3.02 × 10 −5 |
| rs11992725 | COL22A1 | G | A | 0.32 | 1.125 [1.082–1.170] | 2.10 × 10−9 | 1.110 [1.076–1.146] | 7.05 × 10 −11 |
| rs1248634 | DLG5 | G | A | 0.71 | 0.888 [0.854–0.942] | 3.67 × 10−9 | 0.974 [0.942–1.007] | 0.122 |
| rs11187838 | PLCE1 | G | A | 0.57 | 0.894 [0.861–0.928] | 3.64 × 10−9 | 0.9397 [0.912–0.968] | 4.51 × 10 −5 |
| rs7940691 | 5′ EFEMP2 | T | C | 0.36 | 1.113 [1.072–1.155] | 3.50 × 10−8 | 1.005 [0.974–1.037] | 0.766 |
| rs1042602 | TYR | C | A | 0.63 | 0.888 [0.856–0.922] | 1.01 × 10−9 | 0.9499 [0.921–0.9798] | 1.17 × 10 −3 |
| rs10765567 | FAT3 | T | A | 0.37 | 0.841 [0.810–0.873] | 3.13 × 10−18 | 0.874 [0.847–0.901] | 1.64 × 10 −17 |
| rs11217712 | TRIM29–OAF | T | G | 0.31 | 0.892 [0.857–0.927] | 2.65 × 10−8 | 0.970 [0.939–1.002] | 6.73 × 10−2 |
| rs9651980 | 5′ COL2A1 | T | C | 0.087 | 1.188 [1.114–1.267] | 4.72 × 10−8 | 1.052 [0.997–1.110] | 6.01 × 10−2 |
| rs4243042 | LOXL1 | T | A | 0.47 | 0.889 [0.854–0.925] | 3.33 × 10−8 | 0.990 [0.961–1.020] | 0.519 |
EA is the allele on the plus strand for which the effect is reported, ALT is the alternate allele and EAF is the effect allele (EA) frequency in the meta-analysis. Effects obtained from linear mixed models (RD GWAMA) or logistic regression (23andMe) are reported as OR for RD and P is the P-value. CI, 95% confidence interval. In bold, significant replication.