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. 2020 Mar 4;32:101485. doi: 10.1016/j.redox.2020.101485

Fig. 5.

Fig. 5

BC-1901S increases NRF2 abundance in a KEAP1-independent manner. A, B) NRF2 Nano-Luc stably expressed HAP1 WT (A) or KEAP1 KO (B) cells were treated with various concentrations of DMF or BC-1901S for 16 h. Nano-luciferase reagent were then added and luminescence signals were collected and quantified. Data and mean ± SD of 3 independent experiments. C, D) Immunoblots for NRF2 and β-Actin in WT and KEAP1-KO cells treated with DMF or BC-1901S in a dose course. P < 0.05, *; P < 0.001, ***; P < 0.0001, ****; by one-way ANOVA with adjusted P-value for multiple comparisons (Dunnett's) compared to control.