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. 2020 Mar 6;8:128. doi: 10.3389/fcell.2020.00128

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Copyright © 2020 Gao, Lei, Han, He, Jin, Zhang and Jin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Impaired rod maturation in PDE6B patient retinal organoids. (A) Representative immunostaining pictures of the presynaptic marker synaptophysin and rhodopsin (RHO) in retinal organoids. Bar: 25 μm. (B) Amplified presynaptic formation of rod photoreceptors indicated with arrows in (A). Bar: 25 μm. (C) Colocalization of RHO and synaptophysin. (D) Representative immunostaining pictures of the cilium marker ARL13B and RHO in retinal organoids at D230. Bar: 25 μm. Boxes were amplified images. White arrows indicated definite signal of ARL13B represent cilia. Bar: 6.25 μm. (E) Statistic analysis of cilia number in retinal organoids at D230. Statistical results are the mean values ± SD of 3 organoids (3 images each) (D230) of two independent differentiations from the control and patient. Two-tailed t-test, ***P < 0.001.