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. 2020 Mar 6;8:130. doi: 10.3389/fcell.2020.00130

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Copyright © 2020 Dougherty, Patel, Kumar, Rao, Angelos, Singh, Cai and Khan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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EVs derived from hCPCs under physoxia enhances angiogenesis in vitro. BAECs were seeded onto Matrigel-coated wells with 100 μg/ml of total EV protein from each condition and incubated for 16 h. (A) Representative images illustrate the degree of tube formation for each group. (B) 1% O₂-derived EVs significantly increased tube formation in terms of the number of master junctions as compared to No-EVs control. However, 5% O₂-derived EVs significantly increased tube formation as compared to all groups in terms of the number of master junctions, the total master segment length, and the total mesh area. Data shown represents mean ± SD, n = 3, *p < 0.05 for comparison.