| Methods |
Prophylaxis randomised open trial of 536 members of Malvern Boys School in the UK. A/H1N1 was the prevalent viral strain |
| Participants |
Boys aged 13 to 19 years had been previously immunised in the autumn of 1982 (viral strain not reported) |
| Interventions |
Boys were randomised to receive either amantadine 100 mg daily (n = 267 or no treatment n = 269) for 14 days. The trial started on 18 February 1983, as soon as the cases of laboratory‐confirmed influenza were described |
| Outcomes |
Efficacy: case definition is unclear but from the results (Table 2) it would appear that clinical definitions and laboratory isolates were used |
| Notes |
Although the trial was randomised, the design is open and the analysis was not carried out on an intention‐to‐treat basis. Additionally, length of follow up is not reported |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Allocation concealment (selection bias) |
High risk |
C ‐ Inadequate |
