| Methods |
Blinding of randomization: not documented
Blinding of intervention: no. Control patients did not receive a placebo.
Complete follow‐up: yes
Blinding of outcome: not documented
Washout period: 7 days |
| Participants |
Patients entered into the study: n=12
Either mechanical ventilation or continuous positive airway pressure; oxygen supplementation
Entry criteria: CLD, gestational age 24‐28 weeks, postnatal age 21‐68 days
Exclusion criteria: diuretic administration within 7 days, indomethacin administration within 14 days, underlying renal disease, serum creatinine > 0.7 mg/dl (0.062 mmol/L), major congenital anomalies |
| Interventions |
Furosemide and metolazone vs furosemide alone
Patients were randomly allocated to receive either four doses of 1 mg/kg of furosemide intravenously every 24 hours with four doses of 0.2 mg/kg of metolazone enterally every 24 hours (treatment group, N=7), or the same doses of furosemide alone (control, N=5). |
| Outcomes |
Primary outcome: plasma volume, extracellular volume
Secondary outcomes: weight, urine output |
| Notes |
Respiratory parameters were not assessed as part of the study. |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Allocation concealment (selection bias) |
Unclear risk |
Blinding of randomization: not documented |
| Blinding (performance bias and detection bias)
All outcomes |
High risk |
Blinding of intervention: no. Control patients did not receive a placebo.
Blinding of outcome: not documented |
| Incomplete outcome data (attrition bias)
All outcomes |
Low risk |
Complete follow‐up: yes |
