| Methods |
Blinding of randomization: yes
Blinding of intervention: yes
Complete follow up: yes
Blinding of outcome: yes
Randomized controlled trial, parallel design
Washout period: 3‐5 days after last dose of furosemide |
| Participants |
Patients entered into the study: n=33
The need for mechanical ventilation was not used as a criterion.
Entry criteria: Infants with postconceptional age 26‐33 weeks, chronic lung disease (oxygen dependency beyond 28 days), enteral feeding, decision by the attending to prescribe oral diuretic therapy.
Exclusion criteria: renal anomalies known, i.v. fluids, furosemide or early portion of a course of dexamethasone (0.1 to 0.5 mg/kg/day) |
| Interventions |
Thiazide and spironolactone vs thiazide and placebo
Patients were randomly allocated to receive either chlorothiazide 20 mg/kg/day with spironolactone 3 mg/kg/day for 2 weeks (N=17), or chlorothiazide 20 mg/kg/day with placebo for 2 weeks (N=16). |
| Outcomes |
Main outcome: need for electrolyte supplementation; secondary outcome: pulmonary function, serum electrolyte concentration |
| Notes |
Dynamic pulmonary mechanics were measured using an esophageal balloon. |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Unclear risk |
Randomized controlled trial, parallel design |
| Allocation concealment (selection bias) |
Low risk |
Blinding of randomization: yes |
| Blinding (performance bias and detection bias)
All outcomes |
Low risk |
Blinding of intervention: yes
Blinding of outcome: yes |
| Incomplete outcome data (attrition bias)
All outcomes |
Low risk |
Complete follow up: yes |
