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. 2015 Jun 5;2015(6):CD001992. doi: 10.1002/14651858.CD001992.pub3

Asgharnia 2002.

Methods Randomised controlled trial.
Participants 120 women in preterm labour between 24‐32 weeks' gestation with intact membranes and cervical dilation ≥ 2 cm.
Exclusion criteria: PROM, complete cervical dilatation, severe haemorrhage, chorioamnionitis, high‐order multiple pregnancy (≥ triplets), fetal or placental abnormality or sensitivity to tocolytic drugs.
Interventions COX group: indomethacin. 25 mg every 6 h (p.o.) up to maximum of 4 doses.
Control group: MgSO4. Bolus dose of 4 g (i.v.) followed by 2 g/h (i.v.) given in 5% dextrose at 10‐25 µg/min (i.v.).
Both groups: antibiotics as required and 5 mg dexamethasone every 12 h up to 4 doses.
Outcomes Gestational age, mode of delivery, frequency of uterine contractions, dilatation and effacement and delivery delay.
Notes This paper was published in a non‐English language and has been translated for the purpose of this review.
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Unable to determine how randomisation was performed.
Allocation concealment (selection bias) Unclear risk Method of allocation concealment not stated.
Blinding of participants and personnel (performance bias) 
 All outcomes High risk Not stated, but there is no mention of simultaneous placebo treatment to adjust for differences in drug administration and it is likely that participants and personnel were not blinded.
Blinding of outcome assessment (detection bias) 
 All outcomes High risk Not stated, but there is no mention of simultaneous placebo treatment to adjust for differences in drug administration and it is likely that participants and personnel were not blinded.
Incomplete outcome data (attrition bias) 
 All outcomes Low risk All randomised women were included in reporting.
Selective reporting (reporting bias) Unclear risk Unable to determine.
Other bias Unclear risk Unable to determine.