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. 2012 Nov 14;2012(11):CD000265. doi: 10.1002/14651858.CD000265.pub3

Eriksson 1986.

Methods RCT, open design. Outpatient setting in Sweden.
Participants 34 outpatients with chronic venous leg ulcers (9 males,mean age 66.9 years; 25 females, mean age 74.3 years). 3 diabetic patients in Group 2.
Inclusion and exclusion criteria not specified.
Interventions All patients: ulcerated limb immersed for 15 minutes in a bath of tepid potassium permanganate solution, then crusts and debris removed.
Group 1: inner stocking impregnated with zinc oxide paste (ACO) plus an outer elastic bandage (Tensoplast or Porelast Acryl). Bandages changed every 1‐2 weeks (n = 17).
Group 2: hydrocolloid dressing (Duoderm) plus elastic bandage (Wero). Dressing renewed 1‐2 times/week. Bandage removed at night and reapplied in the morning by patients (n = 17).
Outcomes Number (%) patients with complete healing at 12 weeks: Group 1: 7/17 (41%); Group 2: 9/17 (53%). Statistical tests not reported.
Mean decrease in ulcer area:volume at 12 weeks: Group 1: 75%:75%; Group 2: 70%:55% (NB: values recorded from figure; all between‐group differences reported as not statistically significant, but P values not shown).
Number (%) patients who discontinued treatment (with reasons): Group 1: 3/17 (18%) (1 withdrew, 2 had infection of peri‐ulcer skin); Group 2: 2/17 (12%) (1 withdrew, 1 had enlargement of study ulcer and development of new ulcer).
Notes Ulcer area and volume measured using stereophotogrammetry every 2 weeks.
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk "The study was designed as a randomised open trial . . .".
Allocation concealment (selection bias) Unclear risk "The study was designed as a randomised open trial . . .".
Incomplete outcome data (attrition bias) 
 All outcomes Unclear risk For healed outcome, only numerators given, therefore unclear whether all patients followed‐up. Numbers for continuous outcomes unclear.
Blinded outcome assessment (healing) Unclear risk Not stated.
Baseline comparability Unclear risk No baseline data reported.