Figure 6.

Differential core pathways for investigating the progression mechanism between mid-stage colon cancer cells and late-stage colon cancer cells. This figure shows the core pathways in the annotation of Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways extracted from the core genome-wide genetic and epigenetic networks (GWGENs) of mid-stage colon cancer cells and late-stage colon cancer cells. The orange background covers the molecular mechanism in mid-stage colon cancer cells; the purple background covers the core pathways in late-stage colon cancer cells. The green rectangular represents downregulation. The yellow rectangular represents upregulation. The orange lines represent the pathways in mid-stage colon cancer cells; the purple lines represent the pathways in late-stage colon cancer cells; the grey dash lines represent translocation; the green lines with an arrow head stand for activation of function; the green lines with a bar head stand for repression of function; the orange and purple lines with an arrowhead and circle head denote activation and repression of function, respectively; the red lines with a circle mean repression of function; and the yellow stars refer to gene involvement in mutation.