Table 6.

Pathway analysis of proteins in the real genome-wide genetic and epigenetic network (GWGEN) of late-stage colon cancer.

KEGG pathway	Numbers	p-value
MAPK signaling pathway	7	3.4*10-2
Calcium signaling pathway	6	2.8*10-2
HIF-1 signaling pathway	4	6.7*10-2
Signaling pathways regulating pluripotency of stem cells	5	4.4*10-2
Amyotrophic lateral sclerosis (ALS)	3	8.2*10-2
Pathways in cancer	10	1.2*10-2

In the real GWGEN of late-stage colon cancer, the top six enriched Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways were: mitogen-activated protein kinase (MAPK) signaling pathway, calcium signaling pathway, HIF-1 signaling pathway, signaling pathways regulating pluripotency of stem cells, amyotrophic lateral sclerosis (ALS), and pathways in cancer.