Figure 4.

Changes in the VAF of TP53 in the NAC-sensitive and -resistant patient groups. (A) Change of TP53 VAF decreased during treatment in NAC-sensitive groups (blue), whereas the change of TP53 VAF increased during treatment in NAC-resistant groups (red). (B) Significant difference in the change of TP53 VAF was observed between NAC-sensitive (blue) and NAC-resistant (red) patient group (P=0.01). The statistical analyses were performed using the Mann-Whitney U test. P<0.05 was considered to indicate a statistically significant difference. VAF, variant allele frequency; NAC, neoadjuvant chemotherapy.