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. 2020 Jan 30;19(4):2727–2732. doi: 10.3892/ol.2020.11361

Figure 4.

Figure 4.

miR-939-3p directly binds to the 3′UTR of ESR1. (A) Wt and Mut sequences of the ESR1 3′UTR and the binding sequences of miR-939-3p. (B) Correlation of ESR1 and miR-939-3p in The Cancer Genome Atlas. (C) miR-939-3p suppressed the luciferase activity of the Wt ESR1 3′UTR, whereas the Mut miR-939-3p sequence did not in LM3 cells. *P<0.05 vs. NC-mimic (D) mRNA and protein expression levels of ESR1 were reduced following transfection with miR-939-3p mimic, whereas miR-939-3p inhibitor increased ESR1 expression in LM3 cells. *P<0.05 vs. NC. ESR1, Estrogen receptor 1; Wt, wild type; Mut, mutant; NC, negative control; UTR, untranslated region; miR, microRNA.