(b) Module 2 and Module 3
| Biological Process of Module-2 | ||
|---|---|---|
| Term | p Values | Genes |
| positive regulation of protein phosphorylation | 6.67E-05 | EGFR, CCND2, TEK, KDR |
| peptidyl-tyrosine phosphorylation | 1.16E-04 | EGFR, BCR, TEK, KDR |
| protein autophosphorylation | 1.64E-04 | EGFR, BCR, TEK, KDR |
| positive regulation of cell proliferation | 1.65E-04 | EGFR, CCND2, IRS1, KDR, FN1 |
| positive regulation of ERK1 and ERK2 cascade | 1.73E-04 | EGFR, JUN, TEK, KDR |
| positive regulation of GTPase activity | 3.47E-04 | EGFR, BCR, JUN, TEK, IRS1 |
| Angiogenesis | 3.52E-04 | JUN, TEK, KDR, FN1 |
| positive regulation of fibroblast proliferation | 5.48E-04 | EGFR, JUN, FN1 |
| positive regulation of endothelial cell proliferation | 8.94E-04 | JUN, TEK, KDR |
| transmembrane receptor protein tyrosine kinase signaling pathway | 1.72E-03 | EGFR, TEK, KDR |
| Molecular Function of Subnetwork Module-2 | ||
| protein tyrosine kinase activity | 5.51E-05 | EGFR, BCR, TEK, KDR |
| transmembrane receptor protein tyrosine kinase activity | 2.20E-04 | EGFR, TEK, KDR |
| enzyme binding | 8.24E-04 | EGFR, BCR, JUN, WWOX |
| protein binding | 1.45E-03 | EGFR, BCR, CCND2, JUN, TEK, CDH1, TCF4, IRS1, WWOX, KDR, FN1 |
| integrin binding | 1.67E-03 | EGFR, KDR, FN1 |
| Ras guanyl-nucleotide exchange factor activity | 2.00E-03 | EGFR, TEK, IRS1 |
| receptor signaling protein tyrosine kinase activity | 5.91E-03 | EGFR, KDR |
| identical protein binding | 8.26E-03 | EGFR, JUN, TCF4, FN1 |
| growth factor binding | 1.59E-02 | TEK, KDR |
| chromatin binding | 2.13E-02 | EGFR, JUN, TCF4 |
| Cellular Component of Subnetwork Module-2 | ||
| membrane raft | 6.54E-03 | EGFR, TEK, KDR |
| endosome | 7.76E-03 | EGFR, CDH1, KDR |
| apical plasma membrane | 1.27E-02 | EGFR, TEK, FN1 |
| focal adhesion | 2.22E-02 | EGFR, TEK, CDH1 |
| cell junction | 3.00E-02 | BCR, CDH1, KDR |
| microvillus | 3.39E-02 | TEK, WWOX |
| Biological Process of Subnetwork Module-3 | ||
| protein ubiquitination | 3.82E-05 | SH3RF1, LMO7, FBXO32, FBXO9 |
| Molecular Function of Subnetwork Module-3 | ||
| ubiquitin ligase complex | 2.07E-04 | RNF144B, LMO7, FBXO9 |
| SCF ubiquitin ligase complex | 1.09E-02 | FBXO32, FBXO9 |
| Cellular Component of Subnetwork Module-3 | ||
| ubiquitin-protein transferase activity | 2.89E-05 | RNF144B, LMO7, FBXO32, FBXO9 |
| zinc ion binding | 2.62E-02 | SH3RF1, RNF144B, LMO7 |