Table 4.

Effects of PPTT against the subcutaneous B16F10 murine melanoma xenografts.

	Toxicity			Tumor growth
	Maximal body weight change (%)a	Body weight change loss > 20% (%)	Presumed drug related deaths (%)b	rAUC (%)c	Optimal T/C (%)d
NP	−3.3	0	0	69	51
Anti-PD1 mAb	−1.7	0	0	89	68

^aBody weight changes are gains or losses expressed as a percentage of the initial body weight. At each day of weighing, the median value of body weight changes is determined for each experimental group. Then the maximal body weight loss recorded over time is defined. According to NCI criteria, a dose is considered highly toxic if the induced body weight loss is greater than 20% of the initial body weight.

^bA death is presumed to be drug-related if the treated animal died before the control animals. According to NCI, a dose is considered as toxic if the percentage of toxic deaths is higher than 20%.

^crAUC = relative area under the tumor growth curve (expressed as a percentage of the median area under the tumor growth curve of the control group).

^dT/C = (median tumor volume of drug-treated group/median tumor volume of control group) x 100. The optimal T/C is the lowest value, reflecting the maximal tumor growth inhibition.